Table 2.
Association of CMV with Selected Characteristics of the Discovery Cohort
| CMV negative (n = 149) (43%) | CMV positive (n = 198) (57%) | P value | |
|---|---|---|---|
| Age Median (range) | 60 (37.0–91.0) | 64 (37.0–87.0) | P < 0.0001 |
| Gender | |||
| Female | 43 (28.9) | 67 (66.2) | P = 0.32 |
| Male | 106 (71.1) | 131 (33.8) | |
| Binet stage | |||
| A | 71 (47.7) | 109 (55.3) | P = 0.32 |
| B | 72 (48.4) | 83 (42.1) | |
| C | 6 (4.0) | 5 (2.5) | |
| Missing | 0 | 1 | |
| CD38 | |||
| Positive | 34 (25.8) | 48 (28.6) | P = 0.59 |
| Negative | 98 (74.2) | 120 (71.4) | |
| Missing | 17 | 30 | |
| ZAP70 | |||
| Positive | 42 (32.8) | 51 (30.4) | P = 0.65 |
| Negative | 86 (67.2) | 117 (69.6) | |
| Missing | 21 | 30 | |
| IGHV | |||
| Mutated | 81 (35.2) | 95 (61.3) | P = 0.55 |
| Unmutated | 44 (64.8) | 60 (38.7) | |
| Missing | 24 | 43 | |
| CD49d | |||
| Positive | 23 (27.7) | 41 (36.6) | P = 0.19 |
| Negative | 60 (72.3) | 71 (63.4) | |
| Missing | 66 | 86 | |
| FISH | |||
| Normal | 30 (24.4) | 46 (28.6) | P = 0.21 |
| 13q | 50 (40.7) | 70 (43.5) | |
| Trisomy 12 | 25 (20.3) | 25 (15.5) | |
| 11q | 13 (10.6) | 9 (5.6) | |
| 17p | 2 (1.6) | 9 (5.6) | |
| Other | 3 (2.4) | 2 (1.2) | |
| Missing | 26 | 37 | |
| Serum IgG | |||
| N | 95 | 95 | P = 0.63 |
| Mean (SD) | 818.3 (281.3) | 854.4 (316.0) | |
| Median | 820 | 806 | |
| Range | 190.0–1750.0 | 189.0–2220.0 | |
| Missing | 54 | 61 |