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. Author manuscript; available in PMC: 2017 Jun 28.
Published in final edited form as: Cell Rep. 2016 Jun 16;16(1):1–8. doi: 10.1016/j.celrep.2016.05.065

Figure 1. Maternal metabolic syndrome leads to glucose intolerance and altered insulin signaling in the first generation (F1) female offspring.

Figure 1

Metabolic parameters were measured in F0-HF/HS and F0-Con mice prior to mating (A–F) and in the F1 female offspring (G–J). Body weight (A and G), body composition presented as percent fat mass (FM) and fat-free mass (FFM) (B), glucose tolerance test (C and H), and serum insulin (D and I), triglyceride (E), and cholesterol (F) were measured in mice after a 6 h fast. Western blot analysis of tyrosine phosphorylation of IRS1(tyr895) and serine phosphorylation of AKT(ser473) in F1 mixed fiber muscle (J). All data are expressed as mean ± SEM. *P < 0.05 by Student’s T-test.