Table 3.

Risk of incident cancer among women with new-onset atrial fibrillation

	Hazard ratio (95% confidence interval)	P value
All atrial fibrillation events (N=1467)
Crude	1.90 (1.61, 2.24)	<0.001
Age-adjusted	1.58 (1.34, 1.87)	<0.001
Multivariable adjusted*	1.48 (1.25, 1.75)	<0.001
Paroxysmal atrial fibrillation (N=947)
Crude	1.68 (1.36, 2.07)	<0.001
Age-adjusted	1.42 (1.15, 1.75)	0.001
Multivariable adjusted*	1.37 (1.10, 1.69)	0.004
Non-paroxysmal atrial fibrillation (N=520)
Crude	2.22 (1.71, 2.88)	<0.001
Age-adjusted	1.75 (1.35, 2.27)	<0.001
Multivariable adjusted*	1.50 (1.15, 1.96)	0.003

^*Adjusted for age, randomized treatment assignment, education, race/ethnicity and height at study entry, as well as time-dependent measures for body mass index, hypertension, hypercholesterolemia, diabetes, smoking status, number of cigarettes smoked per day, alcohol consumption, physical activity, hormone replacement therapy use, presence of a recent cancer screening test and incident non-fatal cardiovascular events (congestive heart failure, myocardial infarction or stroke). Due to missing data, multivariable models were based on 33789 participants.