Table 4.

Risk of incident cancer subtypes among women with new-onset atrial fibrillation

	Hazard ratio (95% confidence interval)	P value
Incident breast cancer (N=2106)
Age-adjusted	1.35 (1.01, 1.81)	0.04
Multivariable adjusted*	1.32 (0.99, 1.77)	0.06
Incident colon cancer (N=451)
Age-adjusted	2.36 (1.51, 3.68)	<0.001
Multivariable adjusted*	2.11 (1.33, 3.36)	0.002
Incident lung cancer (N=440)
Age-adjusted	1.69 (1.02, 2.81)	0.04
Multivariable adjusted*	1.51 (0.90, 2.54)	0.12

^*Adjusted for age, randomized treatment assignment, education, race/ethnicity and height at study entry, as well as time-dependent measures for body mass index, hypertension, hypercholesterolemia, diabetes, smoking status, number of cigarettes smoked per day, alcohol consumption, physical activity, hormone replacement therapy use, presence of a recent cancer screening test and incident non-fatal cardiovascular events (congestive heart failure, myocardial infarction or stroke). Due to missing data, multivariable models were based on 33789 participants.