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Multistep Synthesis of the Radiolabeling Precursor (S)-4a
aReagents and conditions: (a) tert-butyl 2,2,2-trichloroacetimidate, CH2Cl2, rt, 18 h; (b) Boc2O, KF, NEt3, DMF, rt, 18 h; (c) BH3·THF, 0 °C, 2 h then 1 M NaOH, 30% H2O2, 0 °C, rt, 18 h; (d) TsCl, NaOtBu, CH2Cl2, 0 °C then rt 18 h.
