. 2016 Jul 18;11:3239–3253. doi: 10.2147/IJN.S108143

Table 5.

The in vivo antitumor effects of different groups of ACGs-NSps against 4T1 tumors in mice

Formulation	Tumor weight (g)	Inhibition rate (%)
Negative control	2.117±0.481	NA
HCPT injection (5 mg/kg, iv)	1.026±0.129^*	49.32
ACGs oil solution (4 mg/kg, ig)	1.153±0.224^*	45.53
ACGs-NSps (0.4 mg/kg, iv)	0.586±0.132^,^,^***	74.83
ACGs solution (0.4 mg/kg, iv)	0.456±0.281^,^,^***	78.46^a

Notes: The tumor weight results are presented as the mean ± SD, n=10.

P<0.05 versus blank control,

^**

P<0.01 versus blank control,

^***

P<0.05 versus HCPT injections, and

^****

P<0.05 versus ACGs oil solution.

Based on four surviving mice, data limited for reference only.

Abbreviations: ACGs, annonaceous acetogenins; NSps, nanosuspensions; NA, not applicable; HCPT, hydroxycamptothecin; iv, intravenous; ig, intragastric.