Table S2.

Changes in the zeta potential of ACGs-NSps and ACGs/DiR-NSps in plasma at 37°C

	ζ-potential ± SD (mV)
	ACGs-NSps	ACGs/DiR-NSps
Before mixed with plasma	−20.17±3.12	29.74±5.28
Mixed with plasma 0 h	−5.44±0.82	−4.56±0.56
Mixed with plasma 12 h	−6.60±1.31	−8.75±2.56

Notes: All values are presented as mean ± SD; n=3.

Abbreviations: ACGs-NSps, annonaceous acetogenins nanosuspensions; ACGs/DiR-NSps, annonaceous acetogenins/1,1′-dioctadecyltetramethyl indotricarbocyanine iodide co-encapsulated nanosuspensions; h, hours.