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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: J Allergy Clin Immunol. 2015 Sep 26;137(6):1822–1829.e1. doi: 10.1016/j.jaci.2015.07.041

FIG 1.

FIG 1

Assays to determine functional C1-INH levels, functional α2-macroglobulin levels, and degradation of bradykinin in plasma of patients with HAE-N and control subjects. A, C1-INH functional assay based on inhibition of kallikrein. B, C1-INH functional assay based on inhibition of Factor XIIa. C, α2-Macroglobulin functional assay based on inhibition of kallikrein. D, Degradation of bradykinin by plasma kininases. Assays were performed as described in the Methods section. HAE-N (+) indicates a Factor XII mutation is present, and HAE-N (−) indicates there is no Factor XII mutation. FXIIa, Factor XIIa.