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. Author manuscript; available in PMC: 2017 Feb 9.
Published in final edited form as: Chem Mater. 2015 Dec 14;28(3):727–737. doi: 10.1021/acs.chemmater.5b03528

Table 1.

Molecular Parameters of ABC Triblock Copolypeptoids and the Corresponding Hydrogel Properties

entry # sample compositiona [M1]0:[M2]0:[M3]0:[I]0b Mn(theor.) (kDa)c Mn(NMR) (kDa)d Mn(SEC) (kDa)e PDIe f1f f2f f3f Tgel (°C)g G″ (Pa)h G′ (Pa)h E (Pa)i
1 A98M98D18 100:100:20 20.8 20.0 36.7 1.04 0.47 0.35 0.18 26.2 ± 1.2 36 ± 4 251 ± 23 762 ± 68
2 A92M94D12 100:100:10 18.9 18.1 36.4 1.09 0.50 0.36 0.14 26.6 ± 0.6 58 ± 8 780 ± 46 2346 ± 139
3 A94M158D16 100:150:20 26.0 23.6 41.4 1.09 0.39 0.48 0.13 30.7 ± 1.0 32 ± 1 189 ± 8 573 ± 22
4 A43M92D9 50:100:10 14.0 12.6 29.8 1.08 0.33 0.52 0.14 40.9 ± 1.3 j j j
5 A45M45D10 50:50:10 10.5 9.64 24.1 1.03 0.46 0.34 0.21 31.0 ± 0.3 11 ± 1 125 ± 8 378 ± 23
6 A23M25D5 25:25:5 5.29 5.10 10.3 1.15 0.45 0.36 0.20 > 60.0 j j j
7 A45M47O10 50:50:10 10.2 9.50 26.5 1.06 0.46 0.35 0.18 31.4 ± 0.4 4 ± 1 25 ± 9 76 ± 27
8 A41M47B11 50:50:10 9.64 8.66 28.2 1.06 0.47 0.39 0.14 32.7 ± 0.7 0.07 ± 0.01 0.2 ± 0.04 0.5 ± 0.1
9 A50m55D11 50:50:10 12.7 13.5 26.5 1.07 0.31 0.54 0.15 30.6 ± 0.6 8 ± 1 60 ± 8 182 ± 25
10 A46d42D9 50:50:10 14.9 13.0 26.8 1.07 0.36 0.51 0.14 42.6 ± 1.1 j j j
a

The numbers in subscripts correspond to the DPn of individual block determined by end-group analysis using 1H NMR spectroscopy in CD2Cl2.

b

Initial monomer to initiator ratio.

c

Theoretical molecular weights were calculated from the initial monomer to initiator ratio.

d

Determined by 1H NMR analysis.

e

determinde by the SEC-DRI method using polystyrene standards (0.1 M LiBr/DMF, room temperature).

f

f1, f2, and f3 refer to the weight fraction of the thermoresponsive A end block, the hydrophilic middle block, and the hydrophobic end block, respectively.

g

Tgel is the crossover point of G′ and G″ in the plot of G′ and G″ versus temperature: average of two measurements.

h

G′ and G″ in the gel state at physiological temperature (37 °C): average of two measurements.

i

Young’s modulus is calculated using E = 2G(1 + ν), where G = (G′2+G″2)1/2, ν = 0.5, and ν is the Poisson’s ratio.61

j

The polymer solution did not form a gel at 37 °C.