Table 2. Antigenic impact of introduced substitutions on VNT and LPBE titres.
Substitution and background | Assay | Change caused by substitutions in log2 titre (±SE) for antisera raised against the following viruses | |||
---|---|---|---|---|---|
O UKG/34/2001 | O BFS/1860/67 | O Kau/IC/66 | |||
VP2 T193N | UKG‡ | LPBE | -1.15 (±0.15)* | -1.21 (±0.18) | -0.40 (±0.19) |
UKG | VNT | +0.09 (±0.19) | ND† | ND | |
rO1K | VNT | ND | 0.10 (±0.18) | ND | |
VP3 T223A | UKG | LPBE | -0.75 (±0.14) | -0.02 (±0.18) | -0.04 (±0.17) |
UKG | VNT | 0.01 (±0.19) | ND | ND |
*Significant effects are shown in bold.
†ND = Not Done.
‡O UKG/34/2001.