Table 1. Comparison of demographics and comorbidity between ACOS and non-ACOS cohorts.
| ACOS | |||||
|---|---|---|---|---|---|
| No (N = 42966) | Yes (N = 10751) | ||||
| n | % | n | % | p-value | |
| Sex | 0.97 | ||||
| Women | 19161 | 44.6 | 4792 | 44.6 | |
| Men | 23805 | 55.4 | 5959 | 55.4 | |
| Age, year | 0.99 | ||||
| 20–35 | 1560 | 3.63 | 390 | 3.63 | |
| 35–65 | 17740 | 41.3 | 4435 | 41.3 | |
| ≥65 | 23666 | 55.1 | 5926 | 55.1 | |
| Mean (SD) # | 64.2 (14.4) | 64.6 (14.4) | 0.26 | ||
| Comorbidity | |||||
| AR | 4852 | 11.3 | 3244 | 30.2 | < .0001 |
| AD | 1079 | 2.51 | 441 | 4.10 | < .0001 |
| AC | 9399 | 21.9 | 3080 | 28.6 | < .0001 |
| Alcohol-related illness | 592 | 1.38 | 329 | 3.06 | < .0001 |
| Diabetes | 9568 | 22.3 | 2982 | 27.7 | < .0001 |
| Hypertension | 21166 | 49.3 | 6836 | 63.6 | < .0001 |
| Hyperlipidemia | 11603 | 27.0 | 3698 | 34.4 | < .0001 |
| Pneumonia | 8397 | 19.5 | 4161 | 38.7 | < .0001 |
| IHD | 12042 | 28.0 | 4742 | 44.1 | < .0001 |
| Stroke | 8724 | 20.3 | 3072 | 28.6 | < .0001 |
| PPF | 80 | 0.19 | 57 | 0.53 | < .0001 |
| Cancer | 1476 | 3.44 | 380 | 3.53 | 0.61 |
| HIV infection | 8 | 0.02 | 2 | 0.02 | 0.99 |
Chi-square test
# Student’s t-test.
ACOS, asthma–COPD overlap syndrome; AR, allergic rhinitis; AD, atopic dermatitis; AC, allergic conjunctivitis; IHD, ischemic heart disease; PPF, postinflammatory pulmonary fibrosis.