Fig 3. Effect of borneol on TRPM8 currents in transfected HEK293 cells recorded under inside-out configuration.

(A) Typical recordings of single channel currents at +100 mV and 25°C. Borneol at 100 μM was used. Dashed arrows indicate expansions from underlined region above. (B) Amplitude histograms of the single channel activity. The histograms could not be fitted with a simple Gaussian function, reflecting the existence of multiple conducting states.