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. 2016 Jul 22;11(7):e0159119. doi: 10.1371/journal.pone.0159119

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© 2016 Whitehouse et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 3 — APP_WT/PrP^+/+ and APP_WT/PrP^-/- mice show retention of the pre-synaptic marker synaptophysin (A, D) while APP_Swe.Ind/PrP^+/+ mice reveal disorganization of synaptophysin immunoreactivity (arrow) (G). Astrogliosis and microgliosis are observed in 75 week old APP_Swe.Ind/PrP^+/+ mice, (arrows) (H, I) but not in mice expressing APP_WT/PrP^+/+ and APP_WT/PrP^-/- (B, C, E, F). Section were probed with anti-synaptophysin (A, D, G), anti-GFAP (B, E, H), and anti-Iba1 (C, F, I) antibodies. Figures A,D,G (synaptophysin) x60 magnification scale bar = 20μm, figures B,E,H (GFAP) and C,F,I (Iba1) x40 magnification scale bar = 50μm.