Table 1.
Influence of A. podagraria tincture and metformin on the results of oral glucose tolerance test in rats receiving dexamethasone; Mean ± S.E.M; Q50 (Q25–Q75), n = 5–6 in each group
| Groups | Plasma glucose during oral glucose tolerance test, mmol/l | AUC, mmol × min/l | Average glycemia value, mmol/l | |||
|---|---|---|---|---|---|---|
| Basal level | 30 min | 60 min | 120 min | |||
| Intact control | 4.38 ± 0.54 4.91 (3.42–5.34) |
5.08 ± 0.42 5.34 (4.48–5.83) |
6.37 ± 0.77 6.60 (5.60–6.83) |
3.91 ± 0.35 3.84 (3.54–4.06) |
622 ± 52.8 682 (551–707) |
4.93 ± 0.39 5.34 (4.56–5.44) |
| Dexamethasone | 6.01 ± 0.56 5.44 (4.98–6.68) |
7.56 ± 0.72***
6.60 (6.58–7.86) |
7.23 ± 0.54 6.60 (6.25–8.15) |
6.22 ± 0.43*** 5.87 (5.55–6.63) |
829 ± 54.9* 785 (720–935) |
6.75 ± 0.44** 6.49 (5.83–7.77) |
| Dexamethasone + metformin, 50 mg/kg | 6.27 ± 0.53 6.68 (5.18–7.14)***** |
6.33 ± 0.73 6.58 (5.27–7.04) |
6.09 ± 0.76 6.25 (5.20–6.70) |
4.93 ± 0.33**** 4.91 (4.91–5.11) |
701 ± 69.1 708 (650–742) |
5.83 ± 0.53 5.69 (5.64–6.14) |
| Dexamethasone + A. podagraria tincture, 1 ml/kg | 5.31 ± 0.58 4.78 (4.31–5.81) |
8.20 ± 1.46* 6.49 (5.92–9.49) |
7.18 ± 1.27 6.00 (5.13–8.25) |
6.07 ± 1.05 6.24 (4.79–7.95) |
831 ± 136 724 (611–980) |
6.69 ± 1.05 5.88 (5.00–7.85) |
| Dexamethasone + metformin, 50 mg/kg + A. podagraria tincture, 1 ml/kg | 4.24 ± 0.62 4.35 (3.26–5.17) |
6.68 ± 0.74* 7.53 (6.02–7.68) |
5.26 ± 0.72**** 6.03 (3.66–6.40) |
4.94 ± 0.78 5.11 (4.27–6.29) |
649 ± 62.1 638 (576–757) |
5.28 ± 0.45**** 5.12 (5.11–5.82) |
* – p < 0.05 compared to intact control; ** – p < 0.02 compared to intact control; *** – p < 0.01 compared to intact control
**** – p < 0.05 compared to dexamethasone (untreated); ***** – p < 0.05 compared to the group receiving metformin and A. podagraria tincture
Medians are highlighted in bold