Table 1.

Moderator question key and guide for focus groups on barriers and facilitators to trial participation

1) Prevalent knowledge, understanding, and beliefs about clinical trials
	• Have you heard about clinical trials?
	• What do you understand about clinical trials?
	• How do you feel about clinical trials?
2) Willingness to participate in clinical trials
	• Open to listening
	• Cautious
	• Waiting to say ‘No’
3) Specific probes into facilitators and barriers to participating in clinical trials
	What are the non-trial related factors that you will consider?
	• Your current status of health?
	• Ability and willingness to adhere to trial schedule?
	• Priorities?
	• Opinions of family and friends?
	What are the trial related factors that you will consider?
	• How do you feel about the idea of randomisation?
	• How do you feel about the new treatment?
	• How do you feel about the closer monitoring?
	• How do you feel about more blood tests?