Table 2.

Summary of different genetic model comparison results

SNP	Genetic model	OR (95 % CI)	Z	P value	I 2%	P het	Effect model	Egger’s test
								t value	P value
rs111090870	TT + TC vs. CC	1.12 (1.09–1.15)	7.66	0.000	68.8	<0.001	R	0.42	0.684
	TT vs. TC + CC	1.42 (1.36–1.49)	15.49	0.000	42.6	0.058	F	0.92	0.378
	TT vs. CC	1.36 (1.27–1.45)	9.07	0.000	73.2	<0.001	R	0.98	0.349
	TC vs. CC	1.13 (1.09–1.18)	5.92	0.000	56.3	0.009	R	−0.07	0.949
	T vs. C	1.21 (1.16–1.26)	9.52	0.000	68.7	<0.001	R	0.55	0.597
rs678741	GG + GA vs. AA	0.79 (0.77–9.82)	16.79	0.000	0.0	0.998	F	0.85	0.458
	GG vs. GA + AA	0.69 (0.64–0.74)	10.98	0.000	0.0	0.880	F	−0.82	0.470
	GG vs. AA	0.68 (0.65–0.72)	13.22	0.000	0.0	0.517	F	−1.09	0.356
	GA vs. AA	0.88 (0.85–0.91)	8.12	0.000	0.0	0.904	F	−0.73	0.519
	G vs. A	0.83 (0.81–0.85)	13.75	0.000	0.0	0.743	F	−0.69	0.542
rs11598564	GG + GA vs. AA	1.13 (1.10–1.16)	7.98	0.000	0.0	0.649	F	0.32	0.769
	GG vs. GA + AA	1.09 (0.84–1.43)	0.64	0.519	88.8	<0.001	R	0.29	0.726
	GG vs. AA	1.12 (1.33–1.52)	10.12	0.000	0.0	0.761	F	−0.71	0.526
	GA vs. AA	1.13 (1.08–1.18)	5.34	0.000	0.0	0.739	F	1.02	0.384
	G vs. A	1.21 (1.16–1.25)	10.03	0.000	22.2	0.273	F	0.66	0.557
rs625039	GG + GA vs. AA	1.07 (1.05–1.09)	7.45	0.000	0.0	0.648	F	0.20	0.850
	GG vs. GA + AA	1.30 (1.23–1.37)	9.05	0.000	0.0	0.509	F	1.18	0.303
	GG vs. AA	1.17 (1.13–1.21)	9.48	0.000	0.0	0.651	F	0.66	0.545
	GA vs. AA	1.09 (1.05–1.12)	4.66	0.000	0.0	0.573	F	−0.35	0.747
	G vs. A	1.14 (1.11–1.17)	10.14	0.000	0.0	0.584	F	1.10	0.333

SNP single nucleotide polymorphism; OR odds ratio; CI confidence interval; F fix-effect model; R random-effect model; P _het P value for heterogeneity

P < 0.05 stands for statistical significance