Table 1.
Clinicopathologic and Treatment Factors of Patients Stratified by Receipt of Adjuvant Mitotane
| Variable | All patients (n = 207) | No mitotane (n = 119) | Mitotane (n = 88) | p Value |
|---|---|---|---|---|
| Male | 80 (39) | 45 (38) | 35 (39) | 0.89 |
| Age, y, mean ± SD | 51.3 ± 15.2 | 52.8 ± 14.9 | 49.3 ± 15.5 | 0.10 |
| BMI, kg/m2, mean ± SD | 29.0 ± 8.2 | 29.6 ± 9.2 | 28.3 ± 7.0 | 0.34 |
| ASA class | ||||
| 1 | 30 (21) | 16 (21) | 14 (21) | |
| 2 | 33 (23) | 17 (22) | 16 (24) | |
| 3 | 68 (48) | 36 (47) | 32 (49) | |
| 4 | 12 (8) | 8 (10) | 4 (6) | 0.83 |
| Hormone secretion | 83 (43) | 35 (32) | 48 (58) | 0.001* |
| Familial syndrome | 4 (2) | 2 (2) | 2 (3) | 1.00 |
| Minimally invasive procedure | 38 (19) | 22 (19) | 16 (19) | 0.93 |
| Additional organ resection | 94 (48) | 47 (42) | 47 (55) | 0.08 |
| Intraoperative tumor rupture | 19 (11) | 11 (11) | 8 (10) | 1.00 |
| Tumor size, cm, mean ± SD | 12.1 ± 5.7 | 11.7 ± 5.3 | 12.7 ± 6.1 | 0.24 |
| T1 | 11 (6) | 9 (8) | 2 (3) | 0.17 |
| T2 | 77 (41) | 48 (44) | 29 (36) | |
| T3 | 74 (39) | 39 (36) | 35 (42) | |
| T4 | 27 (14) | 13 (12) | 14 (18) | |
| N1 | 22 (35) | 9 (26) | 13 (46) | 0.15 |
| M1 | 35 (17) | 11 (9) | 24 (28) | 0.001* |
| Stage | ||||
| I | 11 (6) | 9 (8) | 2 (2) | |
| II | 63 (33) | 41 (37) | 22 (27) | |
| III | 59 (31) | 35 (32) | 24 (29) | |
| IV | 59 (31) | 25 (23) | 34 (42) | 0.02* |
| R0 | 127 (69) | 76 (72) | 51 (65) | 0.58 |
| R1 | 47 (26) | 24 (23) | 23 (30) | |
| R2 | 10 (5) | 6 (6) | 4 (5) | |
| Postoperative adrenal insufficiency | 43 (25) | 17 (18) | 26 (34) | 0.02* |
| Complication | 91 (56) | 47 (52) | 44 (60) | 0.44 |
| Adjuvant radiation | 18 (10) | 5 (5) | 13 (17) | 0.01* |
| Adjuvant chemotherapy | 38 (19) | 6 (5) | 32 (37) | <0.001* |
| Death | 94 (46) | 53 (45) | 41 (47) | 0.86 |
| Recurrence | 97 (59) | 53 (55) | 44 (64) | 0.43 |
| Local recurrence | 45 (28) | 24 (26) | 21 (30) | 0.61 |
| Distant recurrence | 69 (42) | 35 (37) | 34 (49) | 0.17 |
Values are n (%) unless otherwise noted.
*
Significant.
ASA, American Society of Anesthesiologists; BMI, body mass index; R0, microscopically negative margin; R1, microscopically positive margin; R2, grossly positive margin.