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. Author manuscript; available in PMC: 2016 Jul 22.
Published in final edited form as: Exp Eye Res. 2016 Apr 1;146:276–282. doi: 10.1016/j.exer.2016.03.023

Fig. 2.

Fig. 2

Total retinal thickness decreased progressively during the extended lifespan beyond 12 months of age in gene therapy treated CLN2-affected dogs. While superior and inferior retinal thickness appears be reduced from normal at 14 months, a statistically significant difference from the normal dogs could not be detected at this age due to the small sample sizes. Thickness measurements were taken 1 optic disc diameter (OD) superior to the ONH and 1 OD inferior to the ONH for each timepoint. Error bars represent standard error of the mean (SEM).