TABLE 3.
Correlation of Hepatic Venous Pressure Gradient With the Patients’ Characteristics and Serological Tests
| Variables | HVPG < 10 mm Hg (n = 129) | HVPG ≥ 10 mm Hg (n = 42) | Univariate Analysis, P | Multivariate Analysis, P |
| Age (years) | 49 (16–84) | 49 (36–69) | 0.281 | — |
| Male sex | 88 (68.75%) | 31 (72.1%) | 0.551 | — |
| Weight (kg) | 63.62 ± 9.2 | 66.98 ± 9.5 | 0.118 | — |
| Height (cm) | 165.66 ± 7.5 | 166.14 ± 8.7 | 0.767 | — |
| BMI (kg/m2) | 23.1 (17.1–33.1) | 24.1 (19.7–32.3) | 0.068 | — |
| ICG-R15% | 13.93 ± 13.9 | 39.11 ± 15.0 | <0.001 | <0.001 |
| Platelet count (×1000) | 241.18 ± 80.7 | 91.89 ± 72.4 | <0.001 | 0.003 |
| PT-INR | 1.06 ± 0.1 | 1.83 ± 0.7 | <0.001 | 0.014 |
| Serum creatinine (mg/dL) | 0.85 ± 0.1 | 0.83 ± 0.2 | 0.612 | — |
| BUN (mg/dL) | 24.61 ± 17.2 | 26.10 ± 18.0 | 0.701 | — |
| Serum total bilirubin (mg/dL) | 0.82 ± 0.3 | 5.24 ± 8.4 | 0.003 | 0.652 |
| Serum AST (U/L) | 43.43 ± 26.1 | 45.67 ± 28.9. | 0.367 | — |
| Serum ALT (U/L) | 45.52 ± 34.2 | 42.40 ± 41.8 | 0.277 | — |
| Serum γ-GT (U/L) | 81.30 ± 34.2 | 79.8 ± 39.8 | 0.432 | — |
| Serum albumin (g/dL) | 4.04 ± 0.4 | 3.12 ± 0.5 | <0.001 | 0.004 |
| Liver histology* | ||||
| Steatosis >10% | 24 (18.9%) | 8 (19%) | 0.797 | |
| Inflammation 0, I, II/III, IV† | 122 (96.1%)/5 (3.9%) | 37 (88.1%)/5 (11.9%) | 0.070 | |
| Fibrosis 0, I, II, III/IV‡ | 89 (70.1%)/38 (29.9%) | 0/42 (100%) | <0.001 |
Data are number (%) or mean ± SD or median (range). Significance was defined as P < 0.05.
*Liver histology was reviewed in 169 liver specimens.
†Inflammation grade: 0, normal; I, minimal; II, mild; III, moderate; and IV, severe.
‡Fibrosis stage: 0, normal; I, portal fibrosis; II, periportal fibrosis; III, septal fibrosis; and IV, cirrhosis.
ALT indicates alanine transaminase; AST, aspartate transaminase; BUN, blood urea nitrogen; γ-GT, gamma-glutamyl transpeptidase; ICG-R15, indocyanine green 15 minutes retention rate; PT-INR, prothrombin time-international normalized ratio.