Table 1.
Formulation | Encapsulation efficiency (%) | Total drug (mg)/100 mg liposome | Particle Size (nm) | Polydispersity | Zeta potential (mV) |
---|---|---|---|---|---|
Blank SPC:Chol:DSPE-PEG2000 | – | – | 127.59 ± 5.98 | 0.24 ± 0.01 | −1.12 ± 0.03 |
SPC:Chol:DSPE-PEG2000:PAC (10:2:0.5) | 65.03 ± 9,93 | 2.01 ± 0.31 | 124.1 ± 4.67 | 0.48 ± 0.02 | −1.26 ± 0.11 |
SPC:Chol:DSPE-PEG2000:RAP (10:2:0.5:1) | 59.58 ± 4.97 | 5.87 ± 0.48 | 133.84 ± 8.35 | 0.26 ± 0.01 | −3.51 ± 0.24 |
SPC:Chol:DSPE-PEG2000:RAP:PAC (10:2:0.5:1:0.33) | 73.31 ± 4.53 (RAP)/56.32 ± 6.32 (PAC) | 7.22 ± 0.45 (RAP)/1.75 ± 0.20 (PAC) | 136.95 ± 7.28 | 0.27 ± 0.01 | 0.02 ± 0.19 |