Estimated sensitivity and specificity of prostate cancer detection depending on screening strategy (prostate-specific antigen (PSA ≥3 ng/ml followed by systematic biopsy, PSA ≥3.0 ng/ml followed by targeted biopsy, and PSA ≥1.8 ng/ml followed by targeted biopsy). Bars indicate 95% confidence intervals for sensitivity (y-axis) and 1-specificity (x-axis).
* PSA = prostate specific antigen, Susp MRI = suspicious magnetic resonance imaging (see ‘Methods’ for details), SB = systematic biopsy, TB = targeted biopsy