. Author manuscript; available in PMC: 2016 Dec 1.

Published in final edited form as: J Enzyme Inhib Med Chem. 2016 Jan 22;31(6):1362–1368. doi: 10.3109/14756366.2015.1135912

Table 2.

Yields from α-alkylation of β-keto esters (6 → 7).

Product	SM	R¹	R²	R⁴	Alkylation (% yield)
7a	6a	Me	Pr	Me	48
7b	6a	Me	Bu	Me	32
7c	6b	Me	CH₂CyPr	iBu	30
7d	6b	Me	CH₂CyBu	iBu	19
7e	6c	CyPr	Me	Me	quant
7f	6c	CyPr	Et	Me	89
7g	6c	CyPr	Pr	Me	78

iBu, isobutyl; CyPr, cyclopropyl; CyBu, cyclobutyl.