Figure 5. Proresolving actions of RvD3 in human cells.
Enhanced macrophage phagocytosis and efferocytosis. Human macrophages (derived from 7 d, 20 ng/mL GMCSF differentiated PBMCs) were incubated with RvD3 (0–10 nM) for 15 min at 37° C followed by addition of (A) fluorescently-labeled E. coli (1:50) or (B) fluorescently-labeled apoptotic PMN (1:50) for 1 hr. Results are mean ± SEM of n=4. **P < 0.01, ***P < 0.001 versus vehicle.
