Table 2.
Multivariate analysis of prognostic factors for OS and PFS
| OS | Intracranial PFS | Extracranial PFS | ||||
|---|---|---|---|---|---|---|
| HR (95 % CI) | p | HR (95 % CI) | p | HR (95 % CI) | p | |
| Age (≥65) | 1.72 (0.74–4.03) | NS | 1.08 (0.60–1.97) | NS | 0.85 (0.49–1.97) | NS |
| Sex (female) | 1.61 (0.55–4.67) | NS | 1.09 (0.66–4.67) | NS | 0.78 (0.48–4.67) | NS |
| Smoking prior or current | 1.09 (0.38–3.12) | NS | 0.99 (0.54–1.80) | NS | 1.62 (1.00–2.61) | NS |
| EGFR mutation (L858R) | 0.42 (0.17–1.03) | NS | 0.84 (0.52–1.36) | NS | 0.98 (0.62–1.56) | NS |
| EGFR TKI (erlotinib) | 0.40 (0.11–1.44) | NS | 0.49 (0.22–1.44) | NS | 0.83 (0.41–1.44) | NS |
| BM lesions (≥5) | 3.36 (1.25–1.208) | 0.016 | 1.65 (0.99–1.44) | NS | 1.07 (0.63–1.44) | NS |
| Extracranial metastasis (yes) | 1.32 (0.44–3.94) | NS | 0.76 (0.38–1.50) | NS | 0.90 (0.48–1.70) | NS |
| ECOG PS (2) | 3.66 (1.73–7.74) | 0.001 | 0.90 (0.36–1.70) | NS | 1.58 (0.66–1.70) | NS |
| Co-existing LMS | 0.78 (0.24 LMS70) | NS | 1.79 (1.03–3.12) | 0.04 | 1.12 (0.61–3.12) | NS |