FIG 5.

PTA (left y axes) for PD targets estimated in PK-PD animal models for the common fungal pathogens A. fumigatus (A), non-albicans Candida (B), and C. albicans (C). Each graph illustrates the proportion of 5,000 simulated subjects achieving each of the PD targets at each MIC value after administration of the clinical dosing regimen of isavuconazonium sulfate. Isavuconazole CLSI MIC distributions (right y axes) are provided for A. fumigatus (n = 855) (A), C. glabrata (n = 254) and C. tropicalis (n = 130) (B), and C. albicans (n = 844) (C).