TABLE 3.
Cocarriage of KPC and other β-lactamases in carbapenem-nonsusceptible Enterobacteriaceae and P. aeruginosa collected in 2012 to 2014
| β-Lactamasesa | Organism | n | Molecular variant(s) |
|---|---|---|---|
| KPC + MBL | K. pneumoniae | 1 | KPC-2, VIM-1 |
| KPC + MBL + ESBL + AmpC + OSBL | K. pneumoniae | 2 | KPC-2, VIM-1, SHV-12, CMY-13, TEM-OSBL |
| KPC + MBL + ESBL | K. oxytocab | 2 | KPC-2, IMP-4, SHV-12 |
| KPC + MBL + AmpC ± OSBL | K. pneumoniae | 1 | KPC-2, VIM-1, MOX-1, SHV-OSBL |
| P. aeruginosac | 1 | KPC-2, VIM-2 | |
| KPC + ESBL-like OXA + ESBL + OSBL | K. pneumoniae | 1 | KPC-2, OXA-163, CTX-M-2, SHV-OSBL, TEM-OSBL |
| KPC + ESBL-like OXA + OSBL | K. pneumoniae | 1 | KPC-2, OXA-163, SHV-OSBL, TEM-OSBL |
| KPC + ESBL + AmpC ± OSBL | C. freundiic | 1 | KPC-2, SHV-12, TEM-OSBL |
| 1 | KPC-2, CTX-M-15 | ||
| 1 | KPC-3, CTX-M-9, SHV-12 | ||
| C. koseric | 1 | KPC-2, CTX-M-3, TEM-OSBL | |
| E. aerogenesc | 1 | KPC-2, VEB-1, TEM-OSBL | |
| E. asburiaec | 2 | KPC-2, SHV-30, TEM-OSBL | |
| E. cloacaec | 1 | KPC-2, SHV-12, DHA-1 | |
| 3 | KPC-2, CTX-M-15, TEM-OSBL | ||
| K. pneumoniae | 2 | KPC-2, CTX-M-15, MOX-2, SHV-OSBL, TEM-OSBL | |
| 1 | KPC-2, CTX-M-27, DHA-1, SHV-OSBL | ||
| KPC + ESBL ± OSBL | E. coli | 1 | KPC-2, CTX-M-15 |
| 1 | KPC-2, CTX-M-15, TEM-OSBL | ||
| K. oxytocab | 4 | KPC-2 | |
| 2 | KPC-2, TEM-OSBL | ||
| 1 | KPC-2, SHV-5, TEM-OSBL | ||
| 1 | KPC-2, SHV-12 | ||
| 1 | KPC-2, CTX-M-8, TEM-OSBL | ||
| 1 | KPC-2, CTX-M-15, TEM-OSBL | ||
| 2 | KPC-3, TEM-OSBL | ||
| K. pneumoniae | 1 | KPC-2, SHV-5, TEM-OSBL | |
| 29 | KPC-2, SHV-12 | ||
| 64 | KPC-2, SHV-12, TEM-OSBL | ||
| 1 | KPC-2, SHV-12, CTX-M-14, TEM-OSBL | ||
| 2 | KPC-2, SHV-12, CTX-M-65 | ||
| 1 | KPC-2, SHV-12, CTX-M-65, TEM-OSBL | ||
| 1 | KPC-2, SHV-28, CTX-M-15, TEM-OSBL | ||
| 3 | KPC-2, CTX-M-2, SHV-OSBL | ||
| 1 | KPC-2, CTX-M-2, TEM-OSBL | ||
| 9 | KPC-2, CTX-M-2, SHV-OSBL, TEM-OSBL | ||
| 1 | KPC-2, CTX-M-2, CTX-M-15, SHV-OSBL, TEM-OSBL | ||
| 2 | KPC-2, CTX-M-3, SHV-OSBL, TEM-OSBL | ||
| 1 | KPC-2, CTX-M-12 | ||
| 2 | KPC-2, CTX-M-12, SHV-OSBL | ||
| 1 | KPC-2, CTX-M-14, TEM-OSBL | ||
| 9 | KPC-2, CTX-M-14, SHV-OSBL, TEM-OSBL | ||
| 10 | KPC-2, CTX-M-15, SHV-OSBL | ||
| 14 | KPC-2, CTX-M-15, SHV-OSBL, TEM-OSBL | ||
| 1 | KPC-2, CTX-M-24, SHV-OSBL | ||
| 2 | KPC-2, CTX-M-65, SHV-OSBL, TEM-OSBL | ||
| 1 | KPC-2, CTX-M-67, SHV-OSBL | ||
| 1 | KPC-2, CTX-M-90, SHV-OSBL, TEM-OSBL | ||
| 1 | KPC-2, GES-6, SHV-OSBL, TEM-OSBL | ||
| 1 | KPC-2, VEB-1, SHV-OSBL | ||
| 16 | KPC-2, VEB-1, SHV-OSBL, TEM-OSBL | ||
| 1 | KPC-3, SHV-12 | ||
| 12 | KPC-3, SHV-12, TEM-OSBL | ||
| 1 | KPC-3, SHV-12, CTX-M-12, TEM-OSBL | ||
| 1 | KPC-3, SHV-28, CTX-M-15, TEM-OSBL | ||
| 1 | KPC-3, CTX-M-2, SHV-OSBL, TEM-OSBL | ||
| 1 | KPC-3, CTX-M-15, SHV-OSBL | ||
| 9 | KPC-3, CTX-M-15, SHV-OSBL, TEM-OSBL | ||
| 2 | KPC-9, VEB-1, SHV-OSBL, TEM-OSBL | ||
| 1 | KPC-12, SHV-2A | ||
| R. ornithinolytica | 1 | KPC-3, SHV-5, TEM-OSBL | |
| KPC + AmpC ± OSBL | C. amalonaticusc | 1 | KPC-2, TEM-OSBL |
| C. farmeric | 1 | KPC-3 | |
| C. freundiic | 4 | KPC-2 | |
| C. koseric | 1 | KPC-2 | |
| E. aerogenesc | 1 | KPC-2 | |
| 1 | KPC-2, TEM-OSBL | ||
| E. asburiaec | 1 | KPC-2 | |
| E. cloacaec | 1 | KPC-2 | |
| 1 | KPC-2, SHV-OSBL | ||
| 3 | KPC-2, TEM-OSBL | ||
| E. coli | 1 | KPC-2, CMY-2 | |
| 1 | KPC-2, CMY-2, TEM-OSBL | ||
| K. pneumoniae | 1 | KPC-2, ACT-type, SHV-OSBL | |
| 1 | KPC-2, CMY-2, SHV-OSBL | ||
| 1 | KPC-2, CMY-2, SHV-OSBL, TEM-OSBL | ||
| 1 | KPC-2, CMY-4, SHV-OSBL | ||
| 1 | KPC-2, DHA-1, SHV-OSBL | ||
| M. morganiic | 1 | KPC-2, TEM-OSBL | |
| S. marcescensc | 2 | KPC-2 | |
| P. aeruginosac | 28 | KPC-2 | |
| KPC ± OSBL | E. coli | 5 | KPC-2 |
| 6 | KPC-2, TEM-OSBL | ||
| 2 | KPC-3 | ||
| 5 | KPC-3, TEM-OSBL | ||
| 2 | KPC-18, TEM-OSBL | ||
| K. pneumoniae | 10 | KPC-2 | |
| 53 | KPC-2, SHV-OSBL | ||
| 3 | KPC-2, TEM-OSBL | ||
| 70 | KPC-2, SHV-OSBL, TEM-OSBL | ||
| 2 | KPC-3 | ||
| 31 | KPC-3, SHV-OSBL | ||
| 4 | KPC-3, TEM-OSBL | ||
| 98 | KPC-3, SHV-OSBL, TEM-OSBL |
a
MBL, metallo-β-lactamase; ESBL, extended-spectrum β-lactamase; OSBL, original spectrum β-lactamase (includes TEM-1, TEM-2, SHV-1, and SHV-11).
b
Presumed to also carry the intrinsic chromosomally encoded ESBL common to this species.
c
Presumed to also carry the intrinsic chromosomally encoded AmpC β-lactamase common to this species.