FIG 7.

Determination of the toxicity of the hit compounds BM04E04 and BM07F03 relative to the control staurosporine in mammalian cell cultures. MTT assays were performed with the indicated dose of drug for 24 h under standard tissue culture conditions as described in Materials and Methods. (A) The control staurosporine concentration ranged from 0.001 to 1 μg/ml in these assays. The hit compound BM04E04 (B) and BM07F03 (C) concentrations ranged from 25 to 800 μg/ml in these assays. The data points represents an average value of assays carried out in triplicate.