TABLE 1.
CYP2B6 c.516G→T allele frequency and EFZ and 8OH-EFZ concentrations in CSF and plasma
| CYP2B6 c.516G→T genotype | Allele frequency (no. [%] of subjects) |
Geometric mean concna (95% CI) |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Plasma |
CSF |
|||||||||
| EFZ |
8OH-EFZ |
EFZ |
8OH-EFZ |
|||||||
| TBM | No TBM | TBM | No TBM | TBM | No TBM | TBM | No TBM | TBM | No TBM | |
| All | 46 (100) | 23 (100) | 2,355,0 (1,836.5–3,047.9) | 1,766.0 (1,383.6–2,280.3) | 1,199.5 (706.3–2,128.1) | 1,194.0 (883.1–1,636.8) | 60.3 (46.6–79.4) | 15.0 (11.7–19.7) | 39.3 (25.7–63.4) | 5.9 (4.4–8.2) |
| GG | 23 (50.0) | 10 (43.5) | 1,694.3 (1,297.2–2,233.6) | 1,264.7 (963.8–1,674.9) | 1,901.1 (1,396.4–2,630.3) | 1,559.6 (1,002.3–2,494.6) | 40.4 (29.4–57.0) | 11.5 (8.5–16.3) | 35.5 (19.1–74.8) | 7.8 (6.0–10.5) |
| GT | 20 (43.5) | 11 (47.8) | 3,140.5 (1,995.3–5,081.6) | 2,202.9 (1,482.5–3,342.0) | 779.8 (269.8–2,766.9) | 1,032.8 (632.4–1,749.8) | 89.3 (61.5–134.0) | 17.0 (11.5–26.6) | 39.8 (21.6–82.8) | 5.3 (3.5–9.2) |
| TT | 3 (6.5) | 2 (8.7) | 4,852.9 (2,716.4–9,036.5) | 3,435.6 (1,625.5–7,834.3) | 666.8 (18.9–1.8 × 106) | 687.1 (15.8–5.2 × 106) | 136.1 (23.6–2,084.5) | 34.8 (5.0–2,546.8) | 82.8 (3.5–5.7 × 106) | 3.3 (1.0–>10 × 106) |
| P valueb | 0.015 | 0.013 | NS | NS | 0.004 | 0.037 | NS | NS | ||
a
All concentrations are with β-glucuronidase. EFZ, efavirenz.
b
P values were determined by ANOVA. NS, not significant.