TABLE 1.
A summary of demographics and dosinga
| Parameter | Model-building data set | Evaluation data set |
|---|---|---|
| No. of subjects | 205 | 163 |
| Wt (kg)b | 2.12 (0.53–5.05) | 2.03 (0.48–5.05) |
| Gestational age (wks)b | 34.0 (23.3–42.1) | 34.3 (23.9–42.3) |
| Postnatal age (days)b | 5.4 (1–66) | 6 (1–78) |
| Postmenstrual age (wks)b | 33.0 (23.3–43.8) | 34.9 (24–43.3) |
| No. (%) of females | 89 (43%) | 68 (41.7%) |
| No. of gentamicin samples per patientc | 6.5 | 3.0 |
| Gentamicin concn (mg/liter)b | 3.4 (0.3–37.6) | 1.0 (0.1–13.2) |
| Time after the dose (h)b | 8.0 (0.02–54.1) | 23.5 (0.08–79.7) |
| No. of occasionsb | 2 (1–22) | 2 (1–7) |
a
Weight and gestational age data represent values at treatment initiation; the rest of the data represent values at the time of gentamicin sampling/dosing. An occasion was defined as a dose with subsequent gentamicin samples taken; day of birth was defined as day 1.
b
Data represent medians (ranges).
c
Data represent means.