TABLE 2.
Final parameter estimates with uncertainty from NONMEM output file and from the bootstrap analysisa
| Parameter | Value from the final model |
Value from the bootstrap analysis |
|||||
|---|---|---|---|---|---|---|---|
| Mean | SE | % CV | η shrinkage | Median | 2.5th percentile | 97.5th percentile | |
| CL (liters/h/70 kg) | 6.21 | 0.30 | 6.14 | 5.47 | 6.75 | ||
| θ_SCr | −0.13 | 0.055 | −0.13 | −0.25 | −0.03 | ||
| PNA50 (days) | 1.70 | 0.30 | 1.68 | 1.15 | 2.30 | ||
| V (liters/70 kg) | 26.5 | 1.11 | 26.3 | 23.6 | 28.4 | ||
| Q (liters/h/70 kg) | 2.15 | 0.32 | 2.19 | 1.68 | 3.25 | ||
| V2 (liters/70 kg) | 21.2 | 1.50 | 20.9 | 17.9 | 24.2 | ||
| Q2 (liters/h/70 kg) | 0.27 | 0.047 | 0.28 | 0.19 | 0.38 | ||
| V3 (liters/70 kg) | 148 | 52.0 | 152 | 65.2 | 534 | ||
| IIV on CL | 0.175 | 0.038 | 41.8 | 6.9 | 0.170 | 0.104 | 0.254 |
| IIV on V | 0.112 | 0.032 | 33.5 | 15.2 | 0.113 | 0.057 | 0.190 |
| CL-V covariance | 0.116 | 0.030 | 0.115 | 0.060 | 0.184 | ||
| IIV on V2 | 0.132 | 0.060 | 36.3 | 57.8 | 0.117 | 0.023 | 0.281 |
| IIV on V3 | 0.177 | 0.216 | 42.1 | 85.0 | 0.114 | 0.00002 | 4.18 |
| Interoccasion variability | 0.014 | 0.007 | 11.8 | 0.013 | 0.001 | 0.029 | |
| Residual error (proportional) | 0.036 | 0.006 | 19.0 | 0.036 | 0.025 | 0.049 | |
| Residual error (additive) | 0.016 | 0.007 | 0.015 | 0.000002 | 0.032 | ||
a
CL, clearance; V, volume of distribution; Q (and Q2), intercompartmental CL; IIV, interindividual variability; SE, standard error obtained with NONMEM 7.3 covariance step; CV, coefficient of variation.