. 2016 Jul 22;60(8):4717–4721. doi: 10.1128/AAC.00202-16

TABLE 2.

Factors associated with a repeat resistant pathogen, by resistance phenotype

Resistance phenotype	Risk factor^a	All isolates			Isolates excluding cultures taken within 14 days of each other
Resistance phenotype	Risk factor^a	Univariate P value	Multivariate P value	Multivariate OR (95% CI)	Univariate P value	Multivariate P value	Multivariate OR (95% CI)
cipro^r	Age	0.033	0.019	1.004 (1.001–1.007)	0.009	0.002	1.006 (1.002–1.010)
	Male gender	<0.001	<0.001	1.288 (1.151–1.440)	<0.001	0.001	1.274 (1.108–1.464)
	Time between cultures	0.014	0.016	1.000 (0.999–1.000)	<0.001	<0.001	0.999 (0.999–1.000)
	Intervening cultures without cipro^r	<0.001	<0.001	0.565 (0.496–0.645)	<0.001	<0.001	0.455 (0.392–0.528)
	ER	0.024	0.508		0.610
	Surgery	0.009	0.406		<0.001	0.292
	ICU	0.017	0.115		0.019	0.008	0.397 (0.201–0.783)
	Medicine	<0.001	0.283		<0.001	0.022	0.796 (0.655–0.968)
ESBL producer	Age	0.011	0.069		0.008	0.062
	Male gender	<0.001	<0.001	1.386 (1.206–1.593)	0.003	0.005	1.271 (1.075–1.501)
	Time between cultures	0.013	<0.001	0.999 (0.999–1.000)	<0.001	<0.001	0.999 (0.999–0.999)
	Intervening cultures without ESBL producer	<0.001	<0.001	0.449 (0.385–0.524)	<0.001	<0.001	0.354 (0.298–0.420)
	ER	<0.001	<0.001	1.552 (1.264–1.905)	0.001	0.018	1.314 (1.048–1.648)
	Surgery	0.017	0.663		0.019	0.957
	ICU	0.215			0.606
	Medicine	0.487			0.900
CRE	Age	0.222			0.904
	Male gender	0.662			0.072
	Time between cultures	<0.001	0.044	0.999 (0.997–1.000)	0.001	0.059
	Intervening cultures without CRE	<0.001	0.002	0.374 (0.200–0.699)	0.001	0.012	0.417 (0.210–0.827)
	ER	0.805			0.949
	Surgery	0.740			0.679
	ICU	1.000			1.000
	Medicine	0.841			0.566
CRNF	Age	0.001	<0.001	0.978 (0.967–0.990)	0.359
	Male gender	0.548			0.718
	Time between cultures	<0.001	<0.001	0.996 (0.994–0.998)	<0.001	0.032	0.998 (0.996–1.000)
	Intervening cultures without CRNF	<0.001	<0.001	0.287 (0.175–0.471)	<0.001	<0.001	0.333 (0.182–0.609)
	ER	0.359			0.935
	Surgery	0.025	0.297		0.027	0.243
	ICU	0.231			1.000
	Medicine	0.019	0.333		0.020	0.235

Odds ratios for the time between cultures are values per day. “ER,” “surgery,” “ICU,” and “medicine” indicate patient locations at the times of second culture.