TABLE 2.
Strong classification markers for the ciprofloxacin resistance data set identified by machine learning analysesa
| Data set (CIPr vs. CIPs) | Gene | SNP positionb | Product | Fold no. |
|---|---|---|---|---|
| SNPs | PA14_23260; gyrA | 2015001 | DNA gyrase subunit A | 5 |
| PA14_20440; phnN | 1758114 | Phosphonate transport ATP-binding protein | 4 | |
| PA14_60790 | 5418859 | Putative ABC transporter, ATP-binding protein | 4 | |
| PA14_25600 | 2238920 | Peptidase | 3 | |
| PA14_34600 | 3074288 | Putative glyceraldehyde-3-phosphate dehydrogenase | 3 | |
| PA14_62810; secG | 5604332 | Preprotein translocase subunit | 3 | |
| PA14_73360; gidB | 6529928 | Glucose-inhibited division protein B | 3 | |
| PA14_08060 | 693759 | Tail fiber assembly protein | 3 | |
| Gene expression | PA14_18480; algX | Alginate biosynthesis protein AlgX | 3 | |
| PA14_32290 | Hypothetical protein | 3 | ||
| PA14_48950 | Hypothetical protein | 3 | ||
| PA14_58410; opdP | Glycine-glutamate dipeptide porin | 3 | ||
| PA14_59390 | Hypothetical protein | 3 | ||
| PA14_62100; yedZ | Sulfide oxidase subunit | 3 |
a
The most frequently selected markers (a minimum of three outer training models [folds]) for differentiation between ciprofloxacin-susceptible and -resistant isolates are listed.
b
For the SNP data set, the genomic position of the mutation in the PA14 reference strain.