TABLE 1.

In vitro inhibition of NS5B-mediated RNA synthesis by nucleoside 5′-triphosphate analogs

NS5B GT	IC50a (μM)
	2′-C-Methyl-DAPN-TP	2′-C-Methyl-GTP	2′-C-Methyl-2′-F-UTP
1b	3.4 ± 1.1	5.6 ± 1.6	2.9 ± 0.6
2a	3.6 ± 2.1	5.1 ± 1.2	3.0 ± 0.9
3a	1.6 ± 0.1	3.6 ± 0.8	7.2 ± 2.1
4a	1.8 ± 1.4	7.4 ± 4.2	12.8 ± 10.7
5a	4.7 ± 3.5	3.5 ± 1.0	ND b
6a	5.1 ± 5.1	2.1 ± 0.4	ND

^aIn vitro IC₅₀s are the averages from two to four replicates ± standard deviations.

^bND, not determined.