TABLE 5.

In vitro inhibition of host DNA polymerase-mediated DNA synthesis

Inhibitor	IC50 (μM)
	DNA Pol α	DNA Pol β	DNA Pol γ
2′-C-Methyl-DAPN-TP	>200	>200	>200
2′-C-Methyl-GTP	>200	>200	>200
2′-C-Methyl-2′-F-UTP	>100	>100	>100
3′-dTTPa	NDb	17.7	41.7
Aphidicolinc	5.4	ND	ND

^a3′-dTTP was used as a positive control for inhibition of DNA synthesis by host DNA polymerase (Pol) β and γ.

^bND, not determined.

^cAphidicolin was used as a positive control for inhibition of DNA synthesis by host DNA polymerase α.