FIG 1.

Mean lung log₁₀ CFU counts (±SD) after 4 and 8 weeks of treatment with bedaquiline- and clofazimine-containing regimens. The main graph does not include results from mice in which bedaquiline and clofazimine cross-resistant mutants were selected after 8 weeks of treatment: 2 and 3 mice from the B and BC groups with mean lung CFU counts of 3.22 ± 0.16 and 2.12 ± 0.69 log₁₀, respectively (inset). The CFU counts at the time of treatment initiation are indicated at day 0. Abbreviations: R, rifampin; H, isoniazid; Z, pyrazinamide; B, bedaquiline; C, clofazimine; L, linezolid; Pa, pretomanid; E, ethambutol; M, moxifloxacin.