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Mean lung log10 CFU counts (±SD) (A and B) and change in CFU counts (week 4 − day 0) (C and D) after 4 weeks of treatment in mice infected with the parental H37Rv strain (A and C) or the B5 mutant (B and D). CFU counts were not determined for untreated mice infected with the parental strain, which required euthanasia prior to the predetermined endpoint. Abbreviations: UT, untreated; H, isoniazid (10 mg/kg); C, clofazimine (20 mg/kg); B, bedaquiline (12.5, 25, or 50 mg/kg).
