FIG 5.

Multiple amino acid sequence alignment for the products of M. tuberculosis pepQ, Lactococcus lactis pepP, and E. coli pepP, constructed using ClustalW. Residues coordinating the Mn²⁺ ions are shown in red. Asterisks indicate positions which have a single, fully conserved residue. Colons indicate conservation between groups of strongly similar properties, scoring >0.5 in the Gonnet PAM 250 matrix. Periods indicate conservation between groups of weakly similar properties, scoring ≤0.5 in the Gonnet PAM 250 matrix.