FIG 2.
Modulation of ML susceptibility by the transporter inhibitor verapamil. Susceptibilities of the wild-type Bristol N2, IVM-selected (IVR10), and MOX-selected strains to IVM and MOX were evaluated with or without the addition of the ABC transporter inhibitor verapamil (VP) (50 μM) in a larval development assay. EC50s in the presence or absence of verapamil for IVM (A) and MOX (B) were calculated as described in Materials and Methods. The bars represent the means ± SD from 3 experiments. *, P < 0.05; **, P < 0.01; ***, P < 0.001 (versus the absence of verapamil).