FIG 3.
Cross-resistance of wild-type Bristol N2, IVM-selected (IVR10), and MOX-selected C. elegans strains to other anthelmintics. A larval development assay was performed on the wild-type Bristol N2, IVM-selected (IVR10), and MOX-selected strains with increasing doses of IVM, MOX, eprinomectin (EPR), levamisole (LEV), triclabendazole sulfoxide (TCBZ So), and albendazole sulfoxide (ALB So). Fold resistances of IVM- and MOX-selected strains relative to the Bristol N2 strain were calculated as ratios of EC50s obtained from the larval development dose-response curves. Data are means ± SD from 3 independent experiments. *, P < 0.05; ***, P < 0.001 (versus the wild type).