TABLE 1.
Pharmacokinetic and pharmacodynamic parameters for single doses of colistin methanesulfonate, tigecycline, and imipenema
| Antimicrobial (dose [mg/kg], route of administration) | Drug form | Cmax (mg/liter) | t1/2 (h) | AUC0–24 (mg · h/liter) | AUC0–24/MICb |
TMIC (h, %)b |
||
|---|---|---|---|---|---|---|---|---|
| Ab9 | Ab186 | Ab9 | Ab186 | |||||
| CMS (20, i.p.) | CMS | 14.24 | 1.12 | 43.24 | 172.97 | 172.97 | ND | ND |
| tCST | 2.87 | 1.1 | 14.41 | 57.63 | 57.63 | ND | ND | |
| fCST | 0.97 | 1.01 | 4.7 | 18.81 | 18.81 | ND | ND | |
| TGC (5, s.c.) | tTGC | 1.34 | 2.04 | 13.75 | 55 | 3.44 | ND | ND |
| IMP (30, i.m.) | tIMP | 26.66 | 0.36 | ND | ND | ND | 1.54, 38.5 | 0.09, 2.25 |
CMS, colistin methanesulfonate; TGC, tigecycline; IMP, imipenem; CST, colistin; tCST, total colistin; fCST, free colistin; tTGC, total tigecycline; tIMP, total imipenem; Cmax, maximum concentration of antimicrobial agent in serum; t1/2, elimination half-life; AUC0–24, area under the concentration-time curve from time zero to 24 h; TMIC, time that the drug concentration remains above the MIC; ND, not determined; i.p., intraperitoneal; s.c., subcutaneous; i.m., intramuscular.
For Ab9, the CST, TGC, and IMP MICs were 0.25, 0.25, and 0.5 mg/liter, respectively. For Ab186, the CST, TGC, and IMP MICs were 0.25, 4, and 16 mg/liter, respectively.