TABLE 5.

Therapeutic effect of LPC in combination with colistin, tigecycline, or imipenem in murine pneumonia model with A. baumannii Ab186

Treatmenta	n	Log10 CFU/g lung (mean ± SEM)	% sterile blood cultures	Mouse survival (%)b
CTL	8	10.93 ± 0.17	0	0*
LPC	8	6.17 ± 0.98c	50c	50c**
CST	15	5.74 ± 1.05c	26.67d	60c**
LPC+CST	15	3.91 ± 0.88c,e	73.33c,e	73.33c**
TGC	14	8.00 ± 0.94	50c	50c**
LPC+TGC	15	5.11 ± 0.94c,e	66.67c	66.67c**
IMP	12	6.85 ± 0.44c	25c,d	100c*
LPC+IMP	15	4.42 ± 0.75c,e	26.67c	100c*

^aCTL, control (no treatment); LPC, lysophosphatidylcholine; CST, colistin; TGC, tigecycline; IMP, imipenem.

^b*, mouse mortality was recorded over 24 h; **, mouse mortality was recorded over 72 h.

^cP < 0.05 compared to the controls.

^dP < 0.05 compared to the LPC group.

^eP < 0.05 compared to the CST, TGC, or IMP group.