TABLE 2.
Mean backcalculated and bias concentrations obtained from 10 calibration curvesa
| Nominal concn (mg/liter) | AMX |
PIP |
OXA |
CLX |
FEP |
CAZ |
CTX |
CFZ |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean calculated concn ± SD (mg/liter) | Bias (%) | Mean calculated concn ± SD (mg/liter) | Bias (%) | Mean calculated concn ± SD (mg/liter) | Bias (%) | Mean calculated concn ± SD (mg/liter) | Bias (%) | Mean calculated concn ± SD (mg/liter) | Bias (%) | Mean calculated concn ± SD (mg/liter) | Bias (%) | Mean calculated concn ± SD (mg/liter) | Bias (%) | Mean calculated concn ± SD (mg/liter) | Bias (%) | |
| 2 | 1.99 ± 0.06 | −0.6 | 2.00 ± 0.06 | 0.2 | 1.99 ± 0.07 | −0.5 | 1.98 ± 0.06 | −0.9 | 1.99 ± 0.07 | −0.7 | 1.99 ± 0.06 | −0.4 | 1.99 ± 0.06 | −0.6 | 1.98 ± 0.07 | −0.9 |
| 5 | 5.07 ± 0.35 | 1.4 | 5.01 ± 0.31 | 0.2 | 5.06 ± 0.34 | 1.3 | 5.11 ± 0.30 | 2.1 | 5.09 ± 0.33 | 1.8 | 5.08 ± 0.31 | 1.5 | 5.08 ± 0.30 | 1.6 | 5.10 ± 0.36 | 1.9 |
| 10 | 9.90 ± 0.47 | −1 | 9.77 ± 0.44 | −2.3 | 9.87 ± 0.56 | −1.3 | 9.93 ± 0.50 | −0.7 | 9.98 ± 0.73 | −0.2 | 9.82 ± 0.54 | −1.8 | 9.91 ± 0.51 | −0.9 | 10.03 ± 0.62 | 0.3 |
| 25 | 25.59 ± 1.34 | 2.3 | 25.36 ± 1.26 | 1.5 | 25.47 ± 1.43 | 1.9 | 25.28 ± 1.32 | 1.1 | 25.23 ± 1.25 | 0.9 | 25.60 ± 1.22 | 2.4 | 25.48 ± 1.25 | 1.9 | 25.30 ± 1.32 | 1.2 |
| 50 | 51.34 ± 1.46 | 2.7 | 50.95 ± 1.06 | 1.9 | 51.06 ± 1.48 | 2.1 | 51.04 ± 1.41 | 2.1 | 50.89 ± 1.65 | 1.8 | 51.25 ± 1.70 | 2.5 | 51.11 ± 1.29 | 2.2 | 51.15 ± 1.19 | 2.3 |
| 75 | 74.78 ± 3.48 | −0.3 | 75.87 ± 3.31 | 1.2 | 74.83 ± 3.34 | −0.2 | 74.97 ± 3.25 | 0 | 74.05 ± 4.54 | −1.3 | 75.21 ± 3.84 | 0.3 | 74.68 ± 3.53 | −0.4 | 74.63 ± 3.58 | −0.5 |
| 100 | 95.46 ± 6.31 | −4.5 | 97.37 ± 5.05 | −2.6 | 96.65 ± 5.82 | −3.3 | 96.20 ± 6.01 | −3.8 | 97.63 ± 5.87 | −2.4 | 95.62 ± 6.77 | −4.4 | 96.16 ± 6.46 | −3.8 | 95.69 ± 6.47 | −4.3 |
a
AMX, amoxicillin; PIP, piperacillin; OXA, oxacillin; CLX, cloxacillin; FEP, cefepime; CAZ, ceftazidime; CTX, cefotaxime; CFZ, cefazolin.