FIG 2.

Efficacy of ND-10885 (compound 6) against M. avium infection in the BALB/c mouse model. M. avium-infected mice were treated with compounds once daily, 6 day per week, for 2 weeks. Bacterial burden in the lung, spleen, and liver was determined. Mock, mice treated with vehicle alone; baseline, bacterial burden at the beginning of treatment; RMP, rifampin. The results are representative of the results from two independent experiments. *, P < 0.05 compared to the mock; **, P < 0.05 compared to ND10885 (at 100 mg/kg) (one-way ANOVA with Tukey posttest). Error bars indicate standard deviations of M. tuberculosis CFU from individual mouse infections (n = 3) with or without drug treatment.