TABLE 1.
Screening of compounds 1 to 6 against two strains of M. avium
| Compound | Molecular mass (kDa) | cLogPa | MIC (μM) |
|
|---|---|---|---|---|
| MAC 101 (serotype 1) | MAC 2151 (serotype 2) | |||
| ND-9873 (1) | 363.34 | 4.6 | 2.8 | 27.5 |
| ND-10885 (2) | 321.38 | 3.6 | 1.6 | 15.6 |
| ND-9758 (3) | 389.43 | 5.8 | 1.28 | 2.57 |
| ND-9759 (4) | 405.88 | 6.4 | 0.31 | 1.2 |
| ND-9903 (5) | 425.41 | 6.4 | >23.5 | >23.5 |
| ND-10890 (6) | 382.44 | 3.4 | 2.6 | 13.1 |
| Rifampin | 822.95 | 6.04 | 0.077 | 0.158 |
| Ethambutol | 204.31 | 0.12 | 48.9 | >48.9 |
| Clarithromycin | 747.95 | 2.82 | 1.4 | 1.4 |
| Azithromycin | 748.88 | 2.28 | 13.4 | >13.4 |
a
cLogP, log of partition coefficient of a compound, was calculated by using ChemBioDraw Ultra 14 (PerkinElmer).