TABLE 1.
MIC distribution of Ureaplasma isolates separated by species
| Species and antimicrobiala | No. (%) of isolates with the indicated MIC (μg/ml) |
MIC50 (μg/ml) | MIC90 (μg/ml) | % susceptibleb | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ≤0.125 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | 16 | >16 | ||||
| U. parvum (n = 202) | ||||||||||||
| LEV | 14 (6.9) | 64 (31.7) | 85 (42.1) | 23 (11.4) | 3 (1.5) | 8 (4) | 4 (2) | 1 (0.5) | 0.5 | 1 | 93.6 | |
| CIP | 4 (2) | 9 (4.4) | 38 (18.8) | 96 (47.5) | 35 (17.3) | 7 (3.5) | 12 (5.9) | 1 (0.5) | 2 | 4 | NA | |
| TET | 161 (79.7) | 29 (14.4) | 8 (4) | 3 (1.5) | 1 (0.5) | ≤0.125 | 0.25 | 99.5 | ||||
| DOX | 194 (96) | 7 (3.5) | 1 (0.5) | ≤0.125 | ≤0.125 | NA | ||||||
| ERY | 8 (4) | 32 (15.8) | 63 (31.2) | 66 (32.7) | 31 (15.3) | 1 (0.5) | 1 (0.5) | 0.5 | 2 | 100 | ||
| AZM | 8 (4) | 41 (20.3) | 66 (32.7) | 57 (28.2) | 28 (3.9) | 1 (0.5) | 1 (0.5) | 0.5 | 2 | NA | ||
| U. urealyticum (n = 48) | ||||||||||||
| LEV | 8 (16.7) | 15 (31.2) | 17 (35.4) | 6 (12.5) | 2 (4.2) | 1 | 2 | 95.8 | ||||
| CIP | 1 (2.1) | 14 (29.2) | 23 (47.9) | 8 (16.7) | 2 (4.2) | 4 | 8 | NA | ||||
| TET | 17 (35.4) | 19 (39.6) | 9 (18.7) | 3 (6.2) | 0.25 | 0.5 | 100 | |||||
| DOX | 48 (100) | ≤0.125 | ≤0.125 | NA | ||||||||
| ERY | 1 (2.1) | 5 (10.4) | 2 (4.2) | 17 (35.4) | 22 (45.8) | 1 (2.1) | 1 | 2 | 100 | |||
| AZM | 1 (2.1) | 5 (10.4) | 5 (10.4) | 17 (35.4) | 20 (41.7) | 1 | 2 | NA | ||||
a
LEV, levofloxacin; CIP, ciprofloxacin; TET, tetracycline; DOX, doxycycline; ERY, erythromycin; AZM, azithromycin; n, number of isolates.
b
NA, not applicable (no CLSI breakpoint).