TABLE 1.
FICI for azithromycin, rifampin, and vancomycin in combination with the LpxC inhibitor PF-5081090
Strain | FICI fora: |
||
---|---|---|---|
AZM + PF-5081090 | RIF + PF-5081090 | VAN + PF-5081090 | |
ATCC 19606 | 0.25 (1/8 MIC AZM + 1/8 MIC PF-5081090) | 0.15 (1/8 MIC AZM + 1/32 MIC PF-5081090) | 0.18 (1/8 MIC AZM + 1/16 MIC PF-5081090) |
Ab-84 | 0.37 (1/8 MIC AZM + 1/4 MIC PF-5081090) | 0.15 (1/8 MIC AZM + 1/32 MIC PF-5081090) | 0.25 (1/8 MIC AZM + 1/8 MIC PF-5081090) |
Ab-108 | 0.25 (1/8 MIC AZM + 1/8 MIC PF-5081090) | 0.14 (1/8 MIC AZM + 1/64 MIC PF-5081090) | 0.25 (1/8 MIC AZM + 1/8 MIC PF-5081090) |
Ab-167 | 0.25 (1/8 MIC AZM + 1/8 MIC PF-5081090) | 0.15 (1/8 MIC AZM + 1/32 MIC PF-5081090) | 0.25 (1/8 MIC AZM + 1/8 MIC PF-5081090) |
Ab-176 | 0.25 (1/8 MIC AZM + 1/8 MIC PF-5081090) | 0.14(1/8 MIC AZM + 1/64 MIC PF-5081090) | 0.25(1/8 MIC AZM + 1/8 MIC PF-5081090) |
Ab-7 | 0.18 (1/8 MIC AZM + 1/16 MIC PF-5081090) | 0.18 (1/8 MIC AZM + 1/16 MIC PF-5081090) | 0.18 (1/8 MIC AZM + 1/16 MIC PF-5081090) |
Ab-31 | 0.18 (1/8 MIC AZM + 1/16 MIC PF-5081090) | 0.15 (1/8 MIC AZM + 1/32 MIC PF-5081090) | 0.18 (1/8 MIC AZM + 1/16 MIC PF-5081090) |
AZM, azithromycin; RMP, rifampin; VAN, vancomycin. Information in parentheses indicates the fractional inhibitory concentration of the antibiotic and PF-5081090 in each combination.