TABLE 1.
Efficacies of tedizolid, vancomycin, and linezolid in a murine subcutaneous catheter-related infection due to MSSA strain Xen29
| Regimen (no. of samples) | Mean log10 no. of CFU/catheter ± SD | P value(s) |
|---|---|---|
| Treatementa | ||
| Control (20) | 7.50 ± 0.33 | |
| Tedizolid phosphate, 10 mg/kg i.v. bid (22) | 5.49 ± 0.62 | <1.37E−07 vs control, <2.74E−07 vs linezolid, <3.61E−09 vs vancomycin |
| Linezolid, 80 mg/kg i.v. bid (20) | 7.41 ± 0.48 | <0.56 vs control |
| Vancomycin, 110 mg/kg s.c. bid (20) | 7.46 ± 0.27 | <0.79 vs control |
| Relapse | ||
| Control (20) | 7.13 ± 0.42 | |
| Tedizolid phosphate, 10 mg/kg i.v. bid (20) | 5.77 ± 0.66 | <6.88E−09 vs control relapse |
a
Treatment lasted 3 days.