TABLE 1.

In vitro activity of POL7001 and comparators against a panel of multidrug-resistant P. aeruginosa CF isolates^a

^aMIC values were determined by the microdilution method in cation-adjusted Mueller-Hinton (MH-II) broth, according to the CLSI guidelines. COL, colistin; GEN, gentamicin; CIP, ciprofloxacin; CAZ, ceftazidime; MER, meropenem; TOB, tobramycin; IMP, imipenem. POL7001 was tested in the presence of 0.002% (vol/vol) P-80 to avoid binding to the plastic. Resistance is indicated with boldface characters (http://www.eucast.org/clinical_breakpoints/). MICs of POL7001 are indicated with gray shading. Times of isolation are indicated as described in Materials and Methods using superscript letters as follows: e, early; i, intermediate; l, late. Genotypes and phenotypes of relevant P. aeruginosa strains are indicated as previously described (10, 11), and the data from the MDR-RP73 strain used for in vivo efficacy studies are indicated with gray shading. ND, not determined.