TABLE 2.
Efficacy of antibiotic treatment in mouse models of acute and chronic P. aeruginosa respiratory infectiona
| Infection category and treatment | Dose (mg/kg) | Time of analysis | No. of mice | CFU/lung (log10) | P value | Total no. of cells | P value | No. of neutrophils | P value | No. of macrophages | P value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MDR-RP73 acute infection—i.t. treatment | |||||||||||
| Saline solution | 4 h | 8 | 6.929 | ||||||||
| POL7001 | 2 | 4 h | 8 | 6.160 | ns | ||||||
| CIP | 8 | 4 h | |||||||||
| Saline solution | 8 h | 8 | 6.579 | ||||||||
| POL7001 | 2 | 8 h | 8 | 5.514 | <0.05 | ||||||
| CIP | 8 | 8 h | |||||||||
| Saline solution | 24 h | 9–16 | 7.172 | 5,777,000 | 5,534,000 | 352,319 | |||||
| POL7001 | 2 | 24 h | 8–16 | 4.247 | <0.001 | 2,862,000 | <0.05 | 2,376,000 | <0.05 | 335,633 | ns |
| CIP | 8 | 24 h | 8 | 5.597 | <0.01 | 6,552,000 | ns | 6,053,000 | ns | 413,412 | ns |
| MDR-RP73 chronic infection—aerosol treatment | |||||||||||
| Saline solution | 7 days | 9 | 4.883 | ||||||||
| POL7001 | 2 | 7 days | 6 | 3.921 | <0.01 | ||||||
| CIP | 8 | 7 days | 11 | 4.113 | <0.05 |
a
All P values indicate P < 0.05. ns, not significant.