TABLE 4.
Efficacy of antibiotic treatment in a CF mouse model of chronic P. aeruginosa respiratory infection
| MDR-RP73 chronic infection—aerosol treatment conditions | Dose (mg/kg) | Time of analysis (no. of days) | No. of mice | CFU/lung (log10) |
P valuea |
|||
|---|---|---|---|---|---|---|---|---|
| Saline solution CF vs non-CF | POL7001 CF vs non-CF | Non-CF POL7001 vs saline solution | CF POL7001 vs saline solution | |||||
| Saline solution (non-CF mice) | 7 | 7 | 5.846 | ns | ||||
| Saline solution (CF mice) | 7 | 5 | 6.263 | ns | ||||
| POL7001 (non-CF mice) | 2 | 7 | 8 | 4.234 | ns | <0.01 | ||
| POL7001 (CF mice) | 2 | 7 | 4 | 4.378 | ns | <0.05 | ||
a
ns, not significant.